1-Bromo-3-chloropropane → HCID 13912832、化合物
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[OH:10].Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:12][CH2:13][CH2:14][Cl:15]参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 2-chloro-4-cyanophenol (2.15 g), 3-bromo-1-chloropropane (2.3 g), dimethylformamide (3 ml) and potassium carbonate (1.5 g) was heated at 100° C. for one hour. After the inorganic salt was filtered off, the solvent was distilled off and the residue was dissolved in chloroform. The solution was chromatographed on a column of silica gel (80 g) and eluted with a solution of petroleum ether-ethyl acetate (10:1) to give 3.06 g of 3-(2-chloro-4-cyanophenoxy)propyl chloride as a colorless oil.
後処理
- filtrationAfter the inorganic salt was filtered off
- distillationthe solvent was distilled off
- dissolutionthe residue was dissolved in chloroform
- customThe solution was chromatographed on a column of silica gel (80 g)
- washeluted with a solution of petroleum ether-ethyl acetate (10:1)
出典と根拠
- ORDレコード
- ord-f1715394539e465f986c3d52adf20013
- 出典データセット
- uspto-grants-1987_06
- 特許番号
- US04672073
反応ノート
読み込み中…