1-Bromo-3-chloropropane → HCID 20197663、化合物
反応式
[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[OH:10].Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:12][CH2:13][CH2:14][Cl:15]参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 2-bromo-4-cyanophenol (3.96 g), 3-bromopropyl chloride (3.46 g), dimethylformamide (20 ml) and anhydrous potassium carbonate (3 g) was heated at 100° C. for 0.5 hour. The inorganic salt was filtered off, and the filtrate was concentrated. The residue was chromatographed on a column of silica gel (90 g), and eluted with a solution of n-hexane-chloroform-acetone (20:10:1) to give 3-(2-bromo-4-cyanophenoxy)propyl chloride as a colorless oil (4.15 g).
後処理
- filtrationThe inorganic salt was filtered off
- concentrationthe filtrate was concentrated
- customThe residue was chromatographed on a column of silica gel (90 g)
- washeluted with a solution of n-hexane-chloroform-acetone (20:10:1)
出典と根拠
- ORDレコード
- ord-5aa517317e3542b298d90c463899e1cf
- 出典データセット
- uspto-grants-1987_06
- 特許番号
- US04672073
反応ノート
読み込み中…