Acetic Acid → 8-Fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-2-[2-(2-pyridinyl) ethyl]-1H-pyrido[4,3-b]indole

HRID 652473ノート

反応式

HRID 652473 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:6]3[CH2:18][CH2:19][NH:20][CH2:21][C:5]=3[C:4]=2[CH:3]=1.[CH:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)=[CH2:23].C(O)(=O)C>CO>[F:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([C:11]3[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=3)[C:6]3[CH2:18][CH2:19][N:20]([CH2:23][CH2:22][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=4)[CH2:21][C:5]=3[C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 75212-VinylpyridineHCID 126299068-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

生成物 1

HCID 139003928-Fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-2-[2-(2-pyridinyl) ethyl]-1H-pyrido[4,3-b]indole収率 89.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (3 g, 0.01 mole), 2-vinylpyridine (1.7 g, 0.01 mol) and 2 mL of glacial acetic acid were refluxed for 48 hours in 30 mL of methanol. The solvent was removed in vacuo and the separated solid was purified by HPLC using ethyl acetate as the eluant to afford 3.5 g (89.9% yield) of the title compound. It was converted to the dihydrochloride salt; mp. 267°-270° C.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe separated solid was purified by HPLC

出典と根拠

ORDレコード
ord-3e53e422c9604183b68682d105ec72ec
出典データセット
uspto-grants-1987_06
特許番号
US04672117

反応ノート

読み込み中…