3-Pyridinehexanamine → 4-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[6-(3-pyridinyl)hexyl]butanamide

HRID 652480ノート

反応式

HRID 652480 の反応式
[C:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)=[C:6]([CH2:17][CH2:18][CH3:19])[C:5]=1[OH:20])(=[O:3])[CH3:2].[N:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[CH:22]=1>>[C:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]([NH:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][C:23]2[CH:22]=[N:21][CH:26]=[CH:25][CH:24]=2)=[O:14])=[C:6]([CH2:17][CH2:18][CH3:19])[C:5]=1[OH:20])(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 135574533-PyridinehexanamineHCID 137538714-(4-Acetyl-3-hydroxy-2-propylphenoxy)butanoic acid

生成物 1

HCID 139127814-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[6-(3-pyridinyl)hexyl]butanamide

実験手順

4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butanoic acid was allowed to react with 3-pyridine hexanamine according to procedure A and the product was purified by chromatography on silica gel to give 4-(4-acetyl-3-hydroxy- 2-propylphenoxy)-N-[6-(3-pyridinyl)hexyl]butanamide, the title compound, mp 69°-71° (from ether-hexane) in 84% yield.

後処理

  1. customthe product was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-80791d5110ef4613b22cc170ce210a8e
出典データセット
uspto-grants-1987_06
特許番号
US04672066

反応ノート

読み込み中…