2-(Pyridin-4-ylsulfanyl)-ethylamine → 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[2-(4-pyridinylthio)ethyl]hexanamide
反応式
[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2].[N:23]1[CH:28]=[CH:27][C:26]([S:29][CH2:30][CH2:31][NH2:32])=[CH:25][CH:24]=1>>[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH:32][CH2:31][CH2:30][S:29][C:26]2[CH:27]=[CH:28][N:23]=[CH:24][CH:25]=2)=[O:16])=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2]参加物
3
実験手順
6-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid was allowed to react with 2-(4-pyridinylthio)ethyl amine according to procedure A and the product was purified by crystallization from ethyl acetate-hexane to give 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[2-(4-pyridinylthio)ethyl]hexanamide, the title compound, mp 63°-65°, in 52% yield.
後処理
- customthe product was purified by crystallization from ethyl acetate-hexane