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Potassium Carbonate → Methyl 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2',4'-Dihydroxy-3'-propylacetophenone | HCID 2775198 | — |
| 反応物 | Methyl 6-Bromohexanoate | HCID 4170292 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoate | HCID 14330007 | 66% |
反応手順
A mixture of 2.72 g of 1-(2,4-dihydroxy-3-propylphenyl) ethanone, 2.72 g of methyl 6-bromohexanoate and 2.90 g of anhydrous potassium carbonate in 30 ml of anhydrous dimethyl formamide was stirred and heated at 75° for 7 hours. The usual workup followed by chromatography on 200 g of silica gel and elution with 10% ethyl acetate-toluene gave 2.77 g (62% yield) of 6-(4-Acetyl-3-hydroxy-2-propylphenoxy) hexanoic acid methyl ester, the titled compound, as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04672066 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-9f71016da67c41e4a3cf6a6260aa0db7 |
| 出典メモ | uspto-grants-1987_06 |