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1-Methylimidazole → 3-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]-2-oxoethyl]-1H-imidazolium chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylimidazole | HCID 1390 | — |
| 反応物 | Methanesulfonamide, N-[4-(2-chloroacetyl)phenyl]- | HCID 116629 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]-2-oxoethyl]-1H-imidazolium chloride | HCID 86741031 | — |
反応手順
Heat a mixture of 160 g (0.646 mole) of N-[4-(2- chloro-1-oxoethyl)phenyl]methanesulfonamide, 55.7 g (0.678 mole) of 1-methyl-1H-imidazole and 2.1 L of acetonitrile at reflux for about 16 hours. Cool the mixture to room temperature and collect the solid and wash with 2 L of acetonitrile. Drying provides the title compound, which may be recrystallized from aqueous ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04613609 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-54ad68dcd9fd4af29864d76629da11a9 |
| 出典メモ | uspto-grants-1986_09 |