1-Methylimidazole → 3-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]-2-oxoethyl]-1H-imidazolium chloride

HRID 65253

反応式

HRID 65253 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][CH:6]=1)=[O:4].[CH3:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>C(#N)C>[Cl-:1].[CH3:16][N:17]1[CH:21]=[CH:20][NH+:19]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][CH:6]=2)=[O:4])[CH2:18]1

参加物

4

反応物 2

HCID 13901-MethylimidazoleHCID 116629Methanesulfonamide, N-[4-(2-chloroacetyl)phenyl]-

生成物 1

HCID 867410313-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]-2-oxoethyl]-1H-imidazolium chloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Heat a mixture of 160 g (0.646 mole) of N-[4-(2- chloro-1-oxoethyl)phenyl]methanesulfonamide, 55.7 g (0.678 mole) of 1-methyl-1H-imidazole and 2.1 L of acetonitrile at reflux for about 16 hours. Cool the mixture to room temperature and collect the solid and wash with 2 L of acetonitrile. Drying provides the title compound, which may be recrystallized from aqueous ethanol.

後処理

  1. temperatureHeat
  2. temperatureat reflux for about 16 hours
  3. customcollect the solid
  4. washwash with 2 L of acetonitrile
  5. customDrying

出典と根拠

ORDレコード
ord-54ad68dcd9fd4af29864d76629da11a9
出典データセット
uspto-grants-1986_09
特許番号
US04613609

関連ノート

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