Hydrochloric Acid → Levamisole

関与物質

反応手順

To a warmed solution, 40° C., of 24.08 g of tetramisole hydrochloride (0.1 mol) in 113 ml. water adjusted to pH 4 with hydrochloric acid was added dropwise during a period of 50 minutes a suspension containing 15.85 g of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (0.05 mol) and 2 g of sodium hydroxide (0.05 mol) in 85 ml of water. The mixture was cooled to 15°-20° C. and additionally stirred during 5 hours. The precipitate was filtered off, washed with water and dried under vacuo at 50° C., yielding 23.55 g of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield=90.3%); αD20 =-63° (c5, 1N HCl); mp. 127.4°-128.1° C.

情報源と証拠