Sodium Methoxide → N-[4-(1-Hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide

HRID 65258

反応式

HRID 65258 の反応式
Cl.O[C:3]1[N:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][CH:11]=2)[CH:5]=[CH:6][N:7]=1.C[O-:22].[Na+]>CO>[OH:22][CH:9]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][CH:11]=1)[CH2:8][N:4]1[CH:5]=[CH:6][N:7]=[CH:3]1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 178505018HCID 178505018、化合物

生成物 1

HCID 13763390N-[4-(1-Hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Heat a mixture of 30.83 g (0.097 mole) of (±)-1-[2- hydroxy-2-[4-((methylsulfonyl)amino)phenyl]ethyl-1H-imidazole hydrochloride and 5.24 g (0.097 mole) of sodium methylate in 100 mL of methanol and filter hot through 300 g of alumina (Fisher, neutral, activity III). Wash the alumina with 20% methanol in methylene chloride (200 mL). Concentrate the filtrate in vacuo to afford the title compound.

後処理

  1. temperatureHeat
  2. filtrationfilter hot through 300 g of alumina (Fisher, neutral, activity III)
  3. washWash the alumina with 20% methanol in methylene chloride (200 mL)
  4. concentrationConcentrate the filtrate in vacuo

出典と根拠

ORDレコード
ord-29b50e3c4fe5489bb62b515e2a560803
出典データセット
uspto-grants-1986_09
特許番号
US04613609

関連ノート

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