3-Benzyloxy-4-methoxybenzaldehyde → 2-Chloro-3-benzyloxy-4-hydroxybenzaldehyde

HRID 652803

反応式

HRID 652803 の反応式
C(OC1C=C(C=CC=1OC)C=O)C1C=CC=CC=1.[Cl:19][C:20]1[C:27]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[C:26]([O:36]C)[CH:25]=[CH:24][C:21]=1[CH:22]=[O:23]>>[Cl:19][C:20]1[C:27]([O:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[C:26]([OH:36])[CH:25]=[CH:24][C:21]=1[CH:22]=[O:23]

参加物

3

反応物 2

HCID 806713-Benzyloxy-4-methoxybenzaldehydeHCID 117478332-Chloro-3-benzyloxy-4-methoxybenzaldehyde

生成物 1

HCID 201963712-Chloro-3-benzyloxy-4-hydroxybenzaldehyde

実験手順

Proceeding as in example 62, but replacing for 3-benzyloxy-4-methoxybenzaldehyde an equivalent quantity of 2-chloro-3-benzyloxy-4-methoxybenzaldehyde (obtained as described in example 84) and purifying the reaction raw product by chromatography on a silica gel column, eluting with methylene chloride/petroleum ether (b.p. 30°-70° C.)=1/1, 2-chloro-3-benzyloxy-4-hydroxybenzaldehyde was obtained, m.p. 149°-150° C. (from methylene chloride/petrolum ether, b.p. 30°-70° C.=1/2).

後処理

  1. custompurifying
  2. customthe reaction raw product by chromatography on a silica gel column
  3. washeluting with methylene chloride/petroleum ether (b.p. 30°-70° C.)=1/1

出典と根拠

ORDレコード
ord-739ed3bb4d6e463d979b86957dd70310
出典データセット
uspto-grants-1987_06
特許番号
US04673671

関連ノート

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