Sinapic acid → Ethyl 3,5-dimethoxy-4-hydroxycinnamate

HRID 652956

反応式

HRID 652956 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:15][CH3:16])[C:13]=1[OH:14])[CH:6]=[CH:7][C:8]([OH:10])=[O:9].S(=O)(=O)(O)O.[CH2:22](O)[CH3:23]>O>[CH3:16][O:15][C:12]1[CH:11]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:13]=1[OH:14])[CH:6]=[CH:7][C:8]([O:10][CH2:22][CH3:23])=[O:9]

参加物

4

反応物 2

HCID 10743Sinapic acidHCID 73950302Sulphuric acid ethanol

生成物 1

HCID 135424Ethyl 3,5-dimethoxy-4-hydroxycinnamate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In an argon atmosphere, 3.00 g (13.4 mmol) of 3,5-dimethoxy-4-hydroxycinnamic acid was suspended in a sulfuric acid - ethanol (1 : 115, 50 ml) solution. The suspension was refluxed for 5.5 hours. Water was added to the reaction solution, and the mixture was extracted with methylene chloride. The organic layer was washed with an aqueous solution of sodium hydrogen carbonate and concentrated under reduced pressure to give 3.34 g (13.24 mmol) of ethyl 3,5-dimethoxy-4-hydroxycinnamate.

後処理

  1. temperatureThe suspension was refluxed for 5.5 hours
  2. extractionthe mixture was extracted with methylene chloride
  3. washThe organic layer was washed with an aqueous solution of sodium hydrogen carbonate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-44042270d45241359e930c29414b599e
出典データセット
uspto-grants-1987_06
特許番号
US04673684

関連ノート

読み込み中…