2-Chloroethanol → Benzhydryl 2-chloroethyl ether

HRID 652961ノート

反応式

HRID 652961 の反応式
[Cl:1][CH2:2][CH2:3][OH:4].S(=O)(=O)(O)O.[CH:10](O)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1C=CC=CC=1>[Cl:1][CH2:2][CH2:3][O:4][CH:10]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 342-ChloroethanolHCID 1118Sulfuric AcidHCID 7037Benzhydrol

生成物 1

HCID 141724Benzhydryl 2-chloroethyl ether収率 100.1%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

反応条件

温度
50 °C

実験手順

To a solution of 3.27 g of 2-chloroethanol in dry benzene (3.5 ml) was added 0.8 g of conc. sulfuric acid and the mixture was heated, under argon atmosphere, at 50° C. To the mixture was added slowly a solution of 5.0 g of benzhydrol in dry benzene (6.5 ml) and, after 30 minutes from the addition, the whole mixture was refluxed for 1.5 hours. After the mixture was allowed to cool, the benzene layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, to give 6.7 g of benzhydryl 2-chloroethyl ether.

後処理

  1. additionafter 30 minutes from the addition
  2. temperaturethe whole mixture was refluxed for 1.5 hours
  3. temperatureto cool
  4. washthe benzene layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-de20cc6f8a87461ca0fe015b58495983
出典データセット
uspto-grants-1987_06
特許番号
US04673684

反応ノート

読み込み中…