Acetyl chloride → Methyl 2-Benzyloxy-2-methylpropionate

HRID 653040ノート

反応式

HRID 653040 の反応式
[CH2:1]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(=O)C>CO>[CH2:1]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([O:12][CH3:15])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 113445632-(Benzyloxy)-2-methylpropanoic acid

生成物 1

HCID 13716841Methyl 2-Benzyloxy-2-methylpropionate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Benzyloxy-2-methylpropionic acid (4.4 g., 0.0023 mol) was dissolved in 50 ml. of methanol treated with acetyl chloride (1.61 ml., 1.78 g., 0.0023 mol), stirred for 16 hours, stripped to an oil, taken up in 75 ml. ethyl acetate, washed 1×50 ml. saturated NaHCO3 and 1×50 ml. brine, dried over MgSO4 and stripped to yield purified title product as a second oil, 4.22 g.; 1H-nmr 1.5 (s, 6H), 3.8 (s, 3H), 4.5 (s, 2H), 7.3-7.5 (m, 5H).

後処理

  1. washethyl acetate, washed 1×50 ml
  2. dry with materialbrine, dried over MgSO4
  3. customto yield
  4. custompurified title product as a second oil, 4.22 g

出典と根拠

ORDレコード
ord-32692ca7e0bc4a0d85e54c68f8d628d3
出典データセット
uspto-grants-1987_06
特許番号
US04675186

反応ノート

読み込み中…