関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| 反応物 | 2-Amino-6-(trifluoromethyl)benzothiazole | HCID 2735955 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-(6-trifluoromethylbenzothiazol-2-yl)-2,6-difluorobenzamide | HCID 13798346 | 78.2% |
反応手順
At 0 to 5° C., 2,6-difluorobenzoyl chloride (1.77 g) was added dropwise to a solution composed of 2-amino-6-trifluoromethylbenzothiazole (2.18 g), tetrahydrofuran (30 ml) and triethylamine (1.1 g). The reaction mixture was stirred at 30 to 40° C. for 5 hours, and then tetrahydrofuran was evaporated. The solid residue was washed with water and recrystallized from ethanol to give the desired N-(6-trifluoromethylbenzothiazol-2-yl)-2,6-difluorobenzamide (2.8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04675331 |
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| 出典データセット | uspto-grants-1987_06 |
|---|
| ORD ID | ord-af5269f2565d4bfc9aeed13fa9888872 |
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| 出典メモ | uspto-grants-1987_06 |
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