Triethylamine → 2-Cyano-2-methylpropionaldoxime N-chloroacetyl-N-methylcarbamate

HRID 653090ノート

反応式

HRID 653090 の反応式
[C:1]([C:3]([CH3:8])([CH3:7])[CH:4]=[N:5][OH:6])#[N:2].[Cl:9][CH2:10][C:11]([N:13]([CH3:17])[C:14](Cl)=[O:15])=[O:12].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:1]([C:3]([CH3:8])([CH3:7])[CH:4]=[N:5][OH:6])#[N:2].[Cl:9][CH2:10][C:11]([N:13]([CH3:17])[C:14](=[O:6])[O-:15])=[O:12]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 13424133N-chloroacetyl-N-methylcarbamoyl chlorideHCID 867406812-Cyano-2-methylpropionaldoxime

生成物 1

HCID 867406802-Cyano-2-methylpropionaldoxime N-chloroacetyl-N-methylcarbamate収率 137%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a mixture of 3.24 g (0.029 m) of 2-cyano-2-methylpropionaldoxime, 5.0 g (0.029 m) of N-chloroacetyl-N-methylcarbamoyl chloride in 50 ml of toluene was added 2.92 g (0.029 m) of triethylamine. After stirring for 2 hours, the solid was filtered. The filter cake was washed with water and hexane and air dried to afford 5.2 g of a white solid with a melting point of 115° C.

後処理

  1. filtrationthe solid was filtered
  2. washThe filter cake was washed with water and hexane and air
  3. customdried

出典と根拠

ORDレコード
ord-811a599c76104344ad03d72216a6bc8e
出典データセット
uspto-grants-1987_06
特許番号
US04675340

反応ノート

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