Triethylamine → 1-Ethoxyacetaldoxime N-chloroacetyl-N-methylcarbamate

HRID 653091

反応式

HRID 653091 の反応式
[OH:1][N:2]=[C:3]([O:5][CH2:6][CH3:7])[CH3:4].[Cl:8][CH2:9][C:10]([N:12]([CH3:16])[C:13](Cl)=[O:14])=[O:11].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:6]([O:5][C:3](=[N:2][OH:1])[CH3:4])[CH3:7].[Cl:8][CH2:9][C:10]([N:12]([CH3:16])[C:13](=[O:1])[O-:14])=[O:11]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 99894Ethyl acetohydroximateHCID 13424133N-chloroacetyl-N-methylcarbamoyl chloride

生成物 1

HCID 867406821-Ethoxyacetaldoxime N-chloroacetyl-N-methylcarbamate収率 167.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 5.0 g (0.05 m) of ethyl N-hydroxyacetimidate and 8.5 g (0.05 m) of N-chloroacetyl-N-methyl-carbamoyl chloride dissolved in 75 ml of toluene was added 5.05 g (0.05 m) of triethylamine. After stirring for 2 hours the reaction mixture was filtered through a bed of Celite. The filtrate was concentrated under reduced pressure to afford 10.3 g of a light yellow crystalline solid. m.p. 69°-71° C.

後処理

  1. filtrationwas filtered through a bed of Celite
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-26fd799f2cc743a1b9ec8635a2954114
出典データセット
uspto-grants-1987_06
特許番号
US04675340

関連ノート

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