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N-Phenylanthranilic Acid → 5-Chloro-3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Phenylanthranilic Acid | HCID 4386 | — |
| 反応物 | 5-Chloro-2-(phenylamino)benzoic acid | HCID 12369456 | — |
| 反応物 | Methyl 3-hydroxy-1-phenyl-1H-indole-2-carboxylate | HCID 54687160 | — |
| 生成物 | 5-Chloro-3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester | HCID 54734281 | — |
反応手順
Prepared in a manner analogous to the multistep procedure described [P. Friedlander and K. Kunz, Chem. Ber., 55, 1597 (1922)] for the preparation of 3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester, with 5-chloro-2-(phenylamino)benzoic acid substituted for 2-(phenylamino)benzoic acid in the first step of the synthetic sequence. The final indole product was recrystallized from aqueous 2-methoxyethanol to yield analytically pure product, mp 170°-173° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04675332 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-d3bdd14ac4ed4593b0ece2902df6fd18 |
| 出典メモ | uspto-grants-1987_06 |