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Hydrochloric Acid → HCID 178425692、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Thiouracil | HCID 1269845 | — |
| 反応物 | 6-Methyl-3-pyridinecarboxaldehyde | HCID 10192566 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178425692 | HCID 178425692 | 45.4% |
反応手順
A mixture of 5 g (0.04 mol) of 2-methyl-5-formylpyridine, 5.29 g (0.04 mol) of 2-thiouracil and 50 ml of concentrated hydrochloric acid was heated overnight. The solution was neutralized with sodium bicarbonate. The organic material in the resulting precipitate was taken up in methanol which was then evaporated to give 4.53 g (45%) of 4-hydroxy-2-mercapto-5-[(6-methyl-3-pyridinyl)hydroxymethyl]pyrimidine [MS(m/e)250]. This compound (2 g) is treated with zinc-acetic acid as in Example 9 to give the same end product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04675406 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-b281c33505d3421fa4ef78bb81481455 |
| 出典メモ | uspto-grants-1987_06 |