1-Octanethiol → 2-(Octylthio)ethyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl)-beta-D-galactopyranoside

HRID 653325ノート

反応式

HRID 653325 の反応式
[C:1]([O:4][C@@H:5]1[C@@H:14]([O:15][C:16](=[O:18])[CH3:17])[C@@H:13]([O:19][C@H:20]2[O:37][C@H:36]([CH2:38][O:39][C:40](=[O:42])[CH3:41])[C@H:31]([O:32][C:33](=[O:35])[CH3:34])[C@H:26]([O:27][C:28](=[O:30])[CH3:29])[C@H:21]2[O:22][C:23](=[O:25])[CH3:24])[C@@H:12]([CH2:43][O:44][C:45](=[O:47])[CH3:46])[O:11][C@H:6]1[O:7][CH2:8][CH2:9]Br)(=[O:3])[CH3:2].[CH2:48]([SH:56])[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55].C(=O)([O-])[O-].[Cs+].[Cs+].C(O[C@@H]1[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H](COC(=O)C)O[C@H]1OCCSCCCCCCCC)(=O)C>[Cl-].C[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC.C1C=CC=CC=1.O>[C:1]([O:4][C@@H:5]1[C@@H:14]([O:15][C:16](=[O:18])[CH3:17])[C@@H:13]([O:19][C@H:20]2[O:37][C@H:36]([CH2:38][O:39][C:40](=[O:42])[CH3:41])[C@H:31]([O:32][C:33](=[O:35])[CH3:34])[C@H:26]([O:27][C:28](=[O:30])[CH3:29])[C@H:21]2[O:22][C:23](=[O:25])[CH3:24])[C@@H:12]([CH2:43][O:44][C:45](=[O:47])[CH3:46])[O:11][C@H:6]1[O:7][CH2:8][CH2:9][S:56][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55])(=[O:3])[CH3:2]

参加物

8

反応物 4

HCID 81441-OctanethiolHCID 10796Cesium carbonateHCID 228870902-Bromoethyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl)-beta-D-galactopyranosideHCID 542299382-(Octylthio)ethyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside

生成物 1

HCID 538927502-(Octylthio)ethyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl)-beta-D-galactopyranoside収率 47.5%

試薬・触媒・溶媒 3

HCID 21218Trioctylmethylammonium chloride触媒HCID 241Benzene溶媒HCID 962Water溶媒

実験手順

Compound 15 (484 mg; 0.65 mmol), octanethiol (110 mg; 0.75 mmol; 130 μl), methyltrioctylammonium chloride (ca 10 mg) and cesium carbonate (245 mg; 0.75 mmol) were dissolved in benzene (1 ml) and water (1 ml). The reaction mixture was treated as for compound 21. Chromatography gave the title compound (23) (250 mg) and starting compound 15 (160 mg). Yield (based on consumed 15): 71%; [α]D21 +65.3° (c 1.4; CHCl3); 1H-NMR (CDCl3, TMS) δ 5.57 (dd, 1H, J4',5' =1 Hz, H4'), 5.39 (dd, 1H, J2', 3'=11 Hz, J3',4' =3.5 Hz, H3'), 5.20 (dd, H1, J1', 2' =3.5 Hz, H2'), 5.19 (dd, 1H, J2,3 =11 Hz, J1,2 =7.5 Hz, H2), 5.01 (d, 1H, J1',2' =3.5 Hz, H1'), 4.81 (dd, 1H, J3,4 =3 Hz, H3), 4.51 (d, 1H, J1,2 =7.5 Hz, H1), 2.73, 2.53 (t, 2H each, J=7 Hz, CH2 --S), 2.13, 2.11, 2.08, 2.08, 2.07, 2.04, 1.99 (s, 3H each, CH3 --CO) ppm. 13C-NMR (CDCl3, TMS) 170.7, 170.6, 170.5, 170.4, 170.1, 169.8, 169.1 (CO), 101.2 (Cl), 99.4 (Cl'), 77.1, 72.7, 71.9, 68.6, 68.6, 67.8, 67.4, 67.1 (C2-C5, C2'-C5'), 69.6 (O--CH2 --CH2 --S), 62.0, 60.5 (C6, C6'), 32.6, 31.8, 31.3, 29.8, 29.2, 28.8, 22.7 (aglycon-CH2), 21.0, 20.8, 20.7 (CH3 --CO), 14.1 (CH3 --CH2) ppm.

出典と根拠

ORDレコード
ord-5bd2d815e70045b58ccd9587f13fbb9f
出典データセット
uspto-grants-1987_06
特許番号
US04675392

反応ノート

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