3-(2-Oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic acid → HCID 13519806、化合物

HRID 653430ノート

反応式

HRID 653430 の反応式
[O:1]=[C:2]1[CH:11](CCC(O)=O)[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1>C(OC(=O)C)(=O)C>[CH2:10]1[C:9]2=[CH:8][CH:7]=[CH:6][C:5]3=[C:4]2[N:3]([C:2](=[O:1])[CH2:11][CH2:10]3)[C:2](=[O:1])[CH2:11]1

参加物

3

反応物 1

HCID 162275833-(2-Oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic acid

生成物 1

HCID 13519806HCID 13519806、化合物

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

反応条件

温度
100 °C

実験手順

1,2,3,4-Tetrahydro-2-oxo-3-quinolinepropanoic acid (2.1 g, 0.0096 mole) is dissolved in acetic anhydride (10 ml) and the solution is heated to 100° C. for one hour. Excess acetic anhydride is removed at reduced pressure and the residual anhydride is removed by addition of toluene and repeated concentration. The solid is recrystallized from ethyl acetate to yield pure 1,2,6,7-tetrahydro-3H,5H-benzo[ij]quinolizine-3,5-dione, mp 136°-140° C.

後処理

  1. customExcess acetic anhydride is removed at reduced pressure
  2. customthe residual anhydride is removed by addition of toluene
  3. concentrationconcentration
  4. customThe solid is recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-f519d34ee95c48e08da8237f2541d28e
出典データセット
uspto-grants-1987_06
特許番号
US04677112

反応ノート

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