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Toluene → Methyl acetate hexane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 2-Nitrobenzenesulfonamide | HCID 138510 | — |
| 反応物 | Dipropan-2-yl (aminomethyl)phosphonate | HCID 13740526 | — |
| 生成物 | Methyl acetate hexane | HCID 23449302 | — |
反応手順
10 g (0.58 mole) of 2-nitrophenylsulfonamide are suspended in 20 ml of toluene and heated to reflux temperature. 17.0 g (0.087 mole) of diisopropyl aminomethylphosphonate are added dropwise to the hot solution. The reaction mixture is then boiled under reflux for 10 hours, cooled and evaporated. Chromatographing the residue over silica gel with a 4:1 methyl acetate/hexane mixture gives 1.6 g of 2-(di-i-propoxyphosphonylmethylamino)-phenylsulfonamide in the form of a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04677217 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-f0454959cd19471f87064f43432f0e9c |
| 出典メモ | uspto-grants-1987_06 |