3-(4-Methoxyphenyl)phenol → (S)-3'-(2-Methyloctanoyloxy)-4-methoxy-1,1'-biphenyl

反応式

[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:16][C@@H:17]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:18](Cl)=[O:19]>>[CH3:16][C@@H:17]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:18]([O:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1)=[O:19]

参加物

反応物 2

HCID 102858703-(4-Methoxyphenyl)phenol2 回

HCID 53713863(S)-2-methyloctanoylchloride

生成物 1

HCID 53720688(S)-3'-(2-Methyloctanoyloxy)-4-methoxy-1,1'-biphenyl

実験手順

Using 3'-hydroxy-4-methoxy-1,1'-biphenyl (4.2 g, 20.4 mmol) obtained in Example 1, (3) and (S)-2-methyloctanoylchloride (4.1 g, 21.5 mmol), the reaction was carried out in the same manner as described in Example 1, (5), to give the title compound as a pale yellow oil; yield: 5.4 g.

出典と根拠

ORDレコード: ord-dd9754bbb34549c781b6f6976e72ce58
出典データセット: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05128062

反応ノート

読み込み中…