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Potassium Carbonate → 2-(3-Chloro-2-methylph-enyl-thiomethyl)-2-imidazoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride | HCID 2760928 | — |
| 反応物 | 3-Chloro-2-methylbenzenethiol | HCID 14878236 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(3-Chloro-2-methylph-enyl-thiomethyl)-2-imidazoline hydrochloride | HCID 14878238 | — |
反応手順
5.55 g (35 mmol) of 3-chloro-2-methyl-thiophenol, 5.43 g (35 mmol) of 2-chloromethyl-2-imidazoline hydrochloride and 5 g of potassium carbonate are stirred in 40 ml of ethanol at room temperature. After 25 h, the mixture is filtered and the filtrate is concentrated to dryness. The crude product is purified by column chromatography on silica gel. After the eluting agent has been stripped off, ethanolic hydrochloric acid is added to the residue and the product is precipitated by addition of ether. White crystals of melting point 208°-209° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05128361 |
| 出典データセット | uspto-grants-1992_07 |
| ORD ID | ord-8929725e1b2f4869a090178749328139 |
| 出典メモ | uspto-grants-1992_07 |