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Hydrochloric Acid → 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-(2-Amino-1-hydroxypropyl)phenol | HCID 11099 | — |
| 反応物 | 1-(Isochroman-1-yl)propan-2-one | HCID 12777063 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol | HCID 19889960 | 72% |
反応手順
An oily product was obtained in the same manner as in Example 1, using (isochroman-1-yl)acetone and 2-amino-1-(4-hydroxyphenyl)-1-propanol [J. Med. Chem., 14, 148 (1971)]. The product was dissolved in anhydrous methanol, and concentrated hydrochloric acid was added thereto. The solvent was evaporated off to give a hydrochloride. The hydrochloride was then washed with ether to give Compound 24 as crystals in a yield of 72%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05128369 |
| 出典データセット | uspto-grants-1992_07 |
| ORD ID | ord-309b8a8a7400410bb9a257c4a7f3f5cf |
| 出典メモ | uspto-grants-1992_07 |