Triethylamine → Methyl 5-methyl-2-valerylaminobenzoate

HRID 653706

反応式

HRID 653706 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(N(CC)CC)C.[C:20](Cl)(=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24]>C(Cl)Cl>[CH3:12][C:9]1[CH:10]=[CH:11][C:2]([NH:1][C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 1201104Methyl 2-Amino-5-methylbenzoate

生成物 1

HCID 19792094Methyl 5-methyl-2-valerylaminobenzoate収率 104.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of methyl 2-amino-5-methylbenzoate (8.1 g) and triethylamine (6.0 g) in methylene chloride (50 ml) was added dropwise, while stirring under ice-cooling, valeryl chloride (6.5 g). The reaction was allowed to stir for two hours, then the reaction mixture was washed with an aqueous solution of sodium carbonate, dilute hydrochloric acid and water, followed by drying. The solvent was evaporated to dryness to give a pale brown oil (12.8 g, 99%).

後処理

  1. temperaturecooling
  2. stirringto stir for two hours
  3. washthe reaction mixture was washed with an aqueous solution of sodium carbonate, dilute hydrochloric acid and water
  4. customby drying
  5. customThe solvent was evaporated to dryness

出典と根拠

ORDレコード
ord-7352affd105141e995fc2529a0f1e185
出典データセット
uspto-grants-1992_07
特許番号
US05128356

関連ノート

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