Triethylamine → HCID 19792116、化合物

HRID 653707ノート

反応式

HRID 653707 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(N(CC)CC)C.[C:20](Cl)(=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24]>C(Cl)Cl>[Cl:12][C:9]1[CH:10]=[CH:11][C:2]([NH:1][C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 78878Methyl 2-amino-5-chlorobenzoate

生成物 1

HCID 19792116HCID 19792116、化合物収率 61%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of methyl 2-amino-5-chlorobenzoate (15 g) and triethylamine (12 ml) in methylene chloride (150 ml) was added dropwise, while stirring under ice-cooling, valeryl chloride (10 ml). The mixture was stirred at room temperature for further two hours. The reaction mixture was washed with an aqueous solution of sodium bicarbonate and water, followed by drying. The solvent was distilled off to afford a pale yellow crystals (13.4 g, 61%), m.p. 48°-49° C.

後処理

  1. temperaturecooling
  2. stirringThe mixture was stirred at room temperature for further two hours
  3. washThe reaction mixture was washed with an aqueous solution of sodium bicarbonate and water
  4. customby drying
  5. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-c6d06f66ba3c45faaa3b50bd8fe3893a
出典データセット
uspto-grants-1992_07
特許番号
US05128356

反応ノート

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