Benzaldehyde → trans-4-Methoxycarbonyl-5-phenyl-2-oxazoline
反応式
C[CH:2]([N+:7]#[C-:8])[C:3]([O:5][CH3:6])=[O:4].[CH:9](=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH3:6][O:5][C:3]([C@H:2]1[C@H:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:16][CH:8]=[N:7]1)=[O:4]参加物
3
実験手順
Methyl α-methylisocyano-acetate was reacted with benzaldehyde in the presence of the same catalyst and under the same reaction conditions of those of Example 2. After the solvent was concentrated, the reaction mixture was subjected to silica-gel column chromatography to obtain trans-4-methoxycarbonyl-5- phenyl-2-oxazoline and the corresponding cis-form in a ratio of 87/13). Total yield: 90%. The optical purity of the trans-(4S,5R) form was measured in the same manner as in Example 1, which was 93% ee.
後処理
- concentrationAfter the solvent was concentrated
出典と根拠
- ORDレコード
- ord-5929a11caa0044a7b0ce4f88af819ad6
- 出典データセット
- uspto-grants-1992_07
- 特許番号
- US05128478
反応ノート
読み込み中…