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4-Fluoro-3-(trifluoromethyl)aniline → 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluoro-3-(trifluoromethyl)aniline | HCID 75377 | — |
| 反応物 | 4-(Chlorosulfonyl)benzoic acid | HCID 82385 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid | HCID 3699990 | 908.4% |
反応手順
Analogously to Example 10, 2.21 g (10 mmol) of 4-chlorosulfonyl-benzoic acid is reacted with 1.79 g (10 mmol) of 4-fluoro-3-(trifluoromethyl)-aniline in pyridine and the crude product is crystallized from ethanol. 3.3 g=90.84 mmol of crystalline product is obtained. Melting point 238°-241° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05130119 |
| 出典データセット | uspto-grants-1992_07 |
| ORD ID | ord-e0350539f1414eb2a75b9ac2d5afcda4 |
| 出典メモ | uspto-grants-1992_07 |