4-Fluoro-3-(trifluoromethyl)aniline → 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid

HRID 654050

反応式

HRID 654050 の反応式
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[F:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][C:16]=1[C:22]([F:25])([F:24])[F:23]>N1C=CC=CC=1>[F:14][C:15]1[CH:21]=[CH:20][C:18]([NH:19][S:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)(=[O:4])=[O:3])=[CH:17][C:16]=1[C:22]([F:23])([F:24])[F:25]

参加物

4

反応物 2

HCID 753774-Fluoro-3-(trifluoromethyl)anilineHCID 823854-(Chlorosulfonyl)benzoic acid

生成物 1

HCID 36999904-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid収率 908.4%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Analogously to Example 10, 2.21 g (10 mmol) of 4-chlorosulfonyl-benzoic acid is reacted with 1.79 g (10 mmol) of 4-fluoro-3-(trifluoromethyl)-aniline in pyridine and the crude product is crystallized from ethanol. 3.3 g=90.84 mmol of crystalline product is obtained. Melting point 238°-241° C.

後処理

  1. customthe crude product is crystallized from ethanol

出典と根拠

ORDレコード
ord-e0350539f1414eb2a75b9ac2d5afcda4
出典データセット
uspto-grants-1992_07
特許番号
US05130119

関連ノート

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