Acetic Anhydride → N-(2,3-Dihydro-1H-inden-2-yl)formamide

HRID 654192ノート

反応式

HRID 654192 の反応式
C(O[C:5](=[O:7])C)(=O)C.Cl.[NH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1.C([O-])(=O)C.[Na+]>C(O)=O>[CH:5]([NH:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1)=[O:7]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 1227642-Aminoindan hydrochlorideHCID 517045Sodium Acetate

生成物 1

HCID 14835235N-(2,3-Dihydro-1H-inden-2-yl)formamide

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

Acetic anhydride (40 ml) and formic acid (20 ml) were mixed and heated at 50° for 15 minutes with stirring. 2-Aminoindane hydrochloride (25 g) (see J. Med. Chem., 1980, 23, page 745) and sodium acetate (20 g) were added to this mixture which was then stirred at room temperature for 24 hours. The reaction mixture was poured into ice/water and extracted three times with methylene chloride. The combined organic layers were washed with water and aqueous sodium carbonate, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 17.6 g, m.p. 72°-74°.

後処理

  1. temperatureheated at 50° for 15 minutes
  2. stirringwas then stirred at room temperature for 24 hours
  3. extractionextracted three times with methylene chloride
  4. washThe combined organic layers were washed with water and aqueous sodium carbonate
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-de49f0190f094a02992453fc6eadb9af
出典データセット
uspto-grants-1992_07
特許番号
US05130334

反応ノート

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