Hydrochloric Acid → HCID 14456701、化合物

HRID 654251ノート

反応式

HRID 654251 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11](Br)[C:12]([OH:14])=O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[NH2:16][C:17](N)=[S:18].Cl.S1(CCCC1)(=O)=[O:22]>O>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH:11]2[S:18][C:17](=[O:22])[NH:16][C:12]2=[O:14])=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2652713-(4-Acetylphenyl)-2-bromopropanoic acidHCID 2723790Thiourea

生成物 1

HCID 14456701HCID 14456701、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 3-(4-acetylphenyl)-2-bromopropanoic acid (87 g, 0.32 mol, prepared according to Cleland, Org. Synth. vol. 51, p. 1, 1971), and thiourea (48.7 g, 0.64 mol) in sulfolane (100 mL) was heated to 105°-110° C. for 5 hours. To this mixture was added a 2N HCl solution (162 mL) and the resulting solution was heated to 105°-110° C. overnight. After cooling and diluting with water, present title product was collected, washed with water and dried (75 g, 94%); mp 171°-172° C.

後処理

  1. temperaturethe resulting solution was heated to 105°-110° C. overnight
  2. temperatureAfter cooling

出典と根拠

ORDレコード
ord-2b51b59555d54f58aa65fcab5fe7893a
出典データセット
uspto-grants-1992_07
特許番号
US05130379

反応ノート

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