Hydrochloric Acid → 1,3,5-Triazin-2-amine, 4-ethoxy-6-(trifluoromethyl)-

HRID 654265ノート

反応式

HRID 654265 の反応式
[NH2:1][C:2]1[N:7]=[C:6](C(Cl)(Cl)Cl)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.[CH2:16]([O-:18])[CH3:17].[Na+].O.Cl>C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([O:18][CH2:16][CH3:17])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2723922Sodium ethoxideHCID 110114464-(trichloromethyl)-6-(trifluoromethyl)-1,3,5-triazin-2-amine

生成物 1

HCID 1999471,3,5-Triazin-2-amine, 4-ethoxy-6-(trifluoromethyl)-

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
20 °C

実験手順

20.0 g (71 mmol) of 2-amino-4-trichloromethyl-6-trifluoromethyl-1,3,5-triazine were added at 22° C. to a solution of 0.48 g (7.1 mmol) of sodium ethanolate in 100 ml of ethanol. The pale yellowish green solution was then refluxed for 30 minutes and, after cooling to 20° C., 20 ml of water were added and the mixture was neutralized with 2 normal hydrochloric acid. After this, most of the solvent was removed at 40° C. under reduced pressure, adding 100 ml of water a little at a time so that the solid did not agglomerate. The product was isolated in a similar manner to Example 2.

後処理

  1. temperatureThe pale yellowish green solution was then refluxed for 30 minutes
  2. customAfter this, most of the solvent was removed at 40° C. under reduced pressure
  3. additionadding 100 ml of water a little at a time so that the solid
  4. customThe product was isolated in a similar manner to Example 2

出典と根拠

ORDレコード
ord-41bd7ecab63d4cb18639d21021e85079
出典データセット
uspto-grants-1992_07
特許番号
US05130428

反応ノート

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