化工社化工社 化学情報印刷レポート · 研究参考用
Monobasic potassium phosphate → Ribavirin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Monobasic potassium phosphate | HCID 516951 | — |
| 反応物 | HCID 178513825 | HCID 178513825 | — |
| 反応物 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol | HCID 178521066 | — |
| 生成物 | Ribavirin | HCID 37542 | 74.88% |
反応手順
After completion of the cultivation, the cells were collected by centrifugation, washed and a sterilized water was added thereto to obtain 250 ml of a cell suspension. Into 750 ml of an aqueous solution containing 66.7 mM 1,2,4-triazole-3-carboxamide, 66.7 mM inosine and 100 mM monopotassium dihydrogen phosphate was added 250 ml of the above cell suspension, and the reaction was carried out at 60° C. for 24 hours (ribavirin yield: 74.88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04614719 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-5d3d90781b2745c6ba6d29a8baff8dd4 |
| 出典メモ | uspto-grants-1986_09 |