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Aniline → 2-Hydroxy-N-phenyl-11H-benzo[A]carbazole-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 2-Hydroxy-11H-benzo[a]carbazole-3-carboxylic acid | HCID 66531 | — |
| 生成物 | 2-Hydroxy-N-phenyl-11H-benzo[A]carbazole-3-carboxamide | HCID 15596992 | — |
反応手順
2-Hydroxy-11H-benzo(a)carbazole-3-carboxylic acid (0.5 gram, 1.8 millimoles) was reacted with aniline (0.44 gram, 4.5 millimoles) in 10 milliliters of o-dichlorobenzene in the presence of a condensing reagent, phosphorus oxychloride (0.37 gram, 2.4 millimoles), at reflux under a nitrogen atmosphere. After 5 hours, TLC analysis revealed that the starting acid was consumed, but that no anilide product, 2-hydroxy-11H-benzo(a)carbazole-3-carboxanilide, was formed.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05130443 |
| 出典データセット | uspto-grants-1992_07 |
| ORD ID | ord-14423a94ba964f5587f7db69a26a6ddf |
| 出典メモ | uspto-grants-1992_07 |