Triethylamine → N6-[(1,2-Dihydro-1-acenaphthylenyl)methyl]adenosine

HRID 65444

反応式

HRID 65444 の反応式
[CH:1]1[N:6]=[C:5](Cl)[C:4]2[N:8]=[CH:9][N:10]([C@@H:11]3[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]3[OH:19])[C:3]=2[N:2]=1.C(N(CC)CC)C.[CH:27]1([CH2:39][NH2:40])[C:37]2=[C:38]3[C:33](=[CH:34][CH:35]=[CH:36]2)[CH:32]=[CH:31][CH:30]=[C:29]3[CH2:28]1>C(O)C>[CH:27]1([CH2:39][NH:40][C:5]2[C:4]3[N:8]=[CH:9][N:10]([C:3]=3[N:2]=[CH:1][N:6]=2)[C@@H:11]2[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]2[OH:19])[C:37]2=[C:38]3[C:33](=[CH:34][CH:35]=[CH:36]2)[CH:32]=[CH:31][CH:30]=[C:29]3[CH2:28]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 930036-Chloropurine ribosideHCID 105593731,2-Dihydro-1-acenaphthylenylmethylamine

生成物 1

HCID 68114916N6-[(1,2-Dihydro-1-acenaphthylenyl)methyl]adenosine収率 85%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Six chloropurine riboside (1.7 g, 6 mmol), triethyl amine (1.5 g, 15 mmol) and the N-[(1,2-dihydro-1-acenaphthylenyl)methyl]amine, B, as prepared in the following Example B (1.4 g, 6.4 mmol) were stirred at reflux in ethanol (100 ml) overnight. The solution was cooled to room temperature and filtered free of solid. The solution was washed with ethanol (50 ml) and dried at 65° C. in vacuo for four hours, to give 2.2 g (85%) of a white solid, mp 173°-175° C. Anal. (C23H23N5O4); calc: C=63.73, H=5.35, N=16.16; found: C=63.55, H=5.49, N=16.00.

後処理

  1. filtrationfiltered free of solid
  2. washThe solution was washed with ethanol (50 ml)
  3. customdried at 65° C. in vacuo for four hours

出典と根拠

ORDレコード
ord-322d46cc4d104fd9b4911580e2e43df7
出典データセット
uspto-grants-1986_09
特許番号
US04614732

関連ノート

読み込み中…