Carbon Tetrachloride → Dimethyl alpha-chloro-alpha-methylmalonate

HRID 654603

反応式

HRID 654603 の反応式
[CH3:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4].[Cl:11]C(Cl)(Cl)Cl>[F-].C([N+](CCCC)(CCCC)CCCC)CCC>[Cl:11][C:2]([CH3:1])([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4]

参加物

4

反応物 2

HCID 5943Carbon TetrachlorideHCID 69104Dimethyl methylmalonate

生成物 1

HCID 10943067Dimethyl alpha-chloro-alpha-methylmalonate収率 63.1%

試薬・触媒・溶媒 1

HCID 2724141Tetrabutylammonium Fluoride触媒

実験手順

In a 10 mL round-bottom flask, a mixture of 1.46 g dimethyl methylmalonate (10 mmol), 1.69 g tetrachloromethane (11 mmol), and 63 mg tetra-n-butylammonium fluoride (0.2 mmol) was mixed by a magnetic stirrer for 15 min at 24° C. Gas chromatographic analysis of the product mixture showed that the solution contained 1.14 g of dimethyl α-chloro-α-methylmalonate (63% yield).

後処理

  1. additionwas mixed by a magnetic stirrer for 15 min at 24° C

出典と根拠

ORDレコード
ord-b04e98ad4b4442ffa79ccdf0dd51c413
出典データセット
uspto-grants-1992_07
特許番号
US05132475

関連ノート

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