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Bromotrichloromethane → Ethyl 2-acetyl-2-bromobutyrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromotrichloromethane | HCID 6383 | — |
| 反応物 | Butanoic acid, 2-ethyl-3-oxo-, ethyl ester | HCID 79065 | — |
| 反応物 | Tetrabutylammonium Fluoride Trihydrate | HCID 11726816 | — |
| 生成物 | Ethyl 2-acetyl-2-bromobutyrate | HCID 11009975 | 56.5% |
反応手順
In a 10 mL round-bottom flask, 1.58 g of ethyl 2-acetylbutyrate (10 mmol), 2.1 g bromotrichloromethane (10.5 mmol), and 200 mg of tetra-n-butylammonium fluoride trihydrate (0.632 mmol) were mixed at 24° C. for 1 h. Gas chromatographic analysis of the resulting mixture showed the presence of 1.34 g of ethyl 2-acetyl-2-bromobutyrate (56% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05132475 |
| 出典データセット | uspto-grants-1992_07 |
| ORD ID | ord-402593d179124bc695f6000a2107b035 |
| 出典メモ | uspto-grants-1992_07 |