Sodium Cyanide → 3-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile

HRID 654623ノート

反応式

HRID 654623 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14])[CH2:6]Cl.[C-:17]#[N:18].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][C:17]#[N:18])[CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 15044966HCID 15044966、化合物

生成物 1

HCID 150449673-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile収率 95%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 16 g of 3-methoxy-5-methylthio-4-propoxybenzyl chloride in 100 ml of dry DMF was added 5 g (0.10 mole) sodium cyanide. The mixture was stirred for about 48 hours at rom temperature under N2. The solution was filtered, and the filtrate was concentrated under vacuum. The residue was purified by flash column chromatography to yield 14.5 g of 3-methoxy-5-methylthio-4-propoxyphenyl acetonitrile as an oil. (95% yield).

後処理

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated under vacuum
  3. customThe residue was purified by flash column chromatography

出典と根拠

ORDレコード
ord-020ee06462ca4e4fa68d3770a9198c20
出典データセット
uspto-grants-1992_07
特許番号
US05132463

反応ノート

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