Benzene, (3-chloro-1-propenyl)- → 1-(Vinylbenzyl)-3-((S)-alpha-methylbenzylcarbamoyl)-pyridinium chloride

HRID 65471

反応式

HRID 65471 の反応式
[CH3:1][C@H:2]([NH:9][C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[N:13][CH:12]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:18][CH2:19][CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CO>[Cl-:18].[CH:20]([CH:21]([N+:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:10](=[O:17])[NH:9][C@@H:2]([CH3:1])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:12]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[CH2:19]

参加物

4

反応物 2

HCID 94242Benzene, (3-chloro-1-propenyl)-HCID 765754N-((S)-alpha-methylbenzyl)nicotinamide

生成物 1

HCID 704518671-(Vinylbenzyl)-3-((S)-alpha-methylbenzylcarbamoyl)-pyridinium chloride収率 89.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

反応条件

温度
25 °C

実験手順

A 100 ml methanol solution containing 2.26 g (1.00×10-2 mols) of N-((S)-α-methylbenzyl)nicotinamide was charged into a 250 ml round bottom flask equipped with condenser, addition funnel, drying tube, nitrogen purge and magnetic stirrer. To this stirred reaction mixture was added, dropwise over a 10 minute interval, 50 ml of a methanol solution containing 1.53 g (1.00×10-2 mols) of chloromethylstyrene. The solution was stirred for 24 hours at 25° C., then was concentrated under vacuum to afford solid which was recrystallized from methanol to yield 3.40 g (8.98×10-3 mols) of product.

後処理

  1. additionwas charged into a 250 ml round bottom flask
  2. customequipped with condenser, addition funnel
  3. customdrying tube
  4. customnitrogen purge
  5. customTo this stirred reaction mixture
  6. concentrationwas concentrated under vacuum
  7. customto afford solid which
  8. customwas recrystallized from methanol

出典と根拠

ORDレコード
ord-5f8417b8409e4cb6abf2aaa05ff224db
出典データセット
uspto-grants-1986_09
特許番号
US04614770

関連ノート

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