Ammonia → HCID 85549673、化合物
反応式
[F:1][CH:2]([C:8](=O)[C:9]([F:12])([F:11])[F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH3:14]>C1(C)C=CC=CC=1>[NH2:14][C:8]([C:9]([F:12])([F:11])[F:10])=[C:2]([F:1])[C:3]([O:5][CH2:6][CH3:7])=[O:4]参加物
4
実験手順
Ethyl 2,4,4,4-tetrafluoro-3-oxobutanoate (81 g.) in toluene (60 ml) was stirred and heated to 70° C. whereupon ammonia gas was bubbled in until an uptake of 6.8 g. was recorded. The reaction was then set for reflux and water removed azeotropically. Approximately 10 ml of water was removed. After cooling, the solvent was removed under reduced pressure and the residue distilled to give ethyl 3-amino-2,4,4,4-tetrafluoro-2-butenoate b.p. 79°-86° C./20 mm, 44 g.
後処理
- customwas bubbled in until an uptake of 6.8 g
- temperaturefor reflux
- customwater removed azeotropically
- customApproximately 10 ml of water was removed
- temperatureAfter cooling
- customthe solvent was removed under reduced pressure
- distillationthe residue distilled
出典と根拠
- ORDレコード
- ord-1c52539500b645c182927bb0d6e9964f
- 出典データセット
- uspto-grants-1992_07
- 特許番号
- US05134145
反応ノート
読み込み中…