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Isopropanol → 3-(3-Ethyl-1,2,4-oxadiazol-5-yl)quinuclidine Hydrogen Oxalate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Methyl quinuclidine-3-carboxylate | HCID 2736953 | — |
| 反応物 | N-Hydroxypropionimidamide | HCID 4092053 | — |
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(3-Ethyl-1,2,4-oxadiazol-5-yl)quinuclidine Hydrogen Oxalate | HCID 14685502 | — |
反応手順
The title compound free base (17 g, 77%) was prepared from methyl quinuclidine-3-carboxylate (18.0 g, 0.11 mol), propionamide oxime (14 g, 0.16 mol) and sodium hydride (7 g of a 55% oil dispersion, 0.16 mol) in anhydrous tetrahydrofuran (350 mL). The hydrogen oxalate salt had mp 113°-115° C. (propan-2-ol). Rf 0.3 in dichloromethane/methanol (50:1) on alumina plates. (Found: C, 52.25; H, 6.41; N, 14.07. C11H17N3O.C2H2O4 requires C, 52.52; H, 6.44; N, 14.13%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05134146 |
| 出典データセット | uspto-grants-1992_07 |
| ORD ID | ord-c7e60a3d7e834c0680725de526ef8f3c |
| 出典メモ | uspto-grants-1992_07 |