化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Hydroxide → O-Coumaric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Ethyl 3-(2-hydroxyphenyl)prop-2-enoate | HCID 576496 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | O-Coumaric Acid | HCID 637540 | 51.9% |
反応手順
To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE043006E1 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-c69e671eabb14e97a6afaf4458a2d516 |
| 出典メモ | uspto-grants-2011_12 |