trans-N-[3-(2-pyridyl)cyclopentyl]phthalimide → trans-3-(2-Pyridyl)cyclopentylamine

HRID 655140ノート

反応式

HRID 655140 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C@H:7]1[CH2:11][CH2:10][C@H:9]([N:12]2C(=O)C3=CC=CC=C3C2=O)[CH2:8]1>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C@H:7]1[CH2:11][CH2:10][C@H:9]([NH2:12])[CH2:8]1

参加物

3

反応物 1

HCID 59486139trans-N-[3-(2-pyridyl)cyclopentyl]phthalimide

生成物 1

HCID 59486146trans-3-(2-Pyridyl)cyclopentylamine収率 92%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of (1S,3S)-N-[3-(2-pyridyl)cyclopentyl]phthalimide (4.12 g, 14.1 mmol), and hydrazinemonohydorate (2.0 mL, 41.2 mmol) in EtOH (100 mL) was stirred at reflux for 3 h. After cooling, the reaction mixture was filtered followed by the removal of solvent. The residue was suspended in EtOAc and stirred at reflux for 1 h. After cooling, the precipitate was filtered followed by the removal of solvent to yield (1S,3S)-3-(2-pyridyl)cyclopentylamine (2.10 g, 92%) as yellow oil.

後処理

  1. temperatureat reflux for 3 h
  2. temperatureAfter cooling
  3. filtrationthe reaction mixture was filtered
  4. customfollowed by the removal of solvent
  5. stirringstirred
  6. temperatureat reflux for 1 h
  7. temperatureAfter cooling
  8. filtrationthe precipitate was filtered
  9. customfollowed by the removal of solvent

出典と根拠

ORDレコード
ord-639706d2eda34aa3b51b7f23f33c5701
出典データセット
uspto-grants-2011_12
特許番号
US08071591B2

反応ノート

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