trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide → trans-3-(3-Pyridyl)cyclohexylamine

HRID 655171ノート

反応式

HRID 655171 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([N:13]3C(=O)C4=CC=CC=C4C3=O)[CH2:8]2)[CH:2]=1>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([NH2:13])[CH2:8]2)[CH:2]=1

参加物

3

反応物 1

HCID 67133459trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide

生成物 1

HCID 67133702trans-3-(3-Pyridyl)cyclohexylamine収率 62.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide (3.00 g, 9.79 mmol) and hydrazinemonohydorate (0.95 mL, 19.6 mmol) in EtOH (40 mL) was stirred at room temperature for 1.5 h. The reaction mixture was filtered followed by the removal of solvent. The crude product was purified by column chromatography (NH, EtOAc) to yield trans-3-(3-pyridyl)cyclohexylamine (1.08 g, 60%) as colorless oil.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customfollowed by the removal of solvent
  3. customThe crude product was purified by column chromatography (NH, EtOAc)

出典と根拠

ORDレコード
ord-74dd4d4486cf4557ae5649deffc813e6
出典データセット
uspto-grants-2011_12
特許番号
US08071591B2

反応ノート

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