cis-N-[3-(3-pyridyl)cyclohexyl]phthalimide → cis-3-(3-Pyridyl)cyclohexylamine

HRID 655175ノート

反応式

HRID 655175 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([N:13]3C(=O)C4=CC=CC=C4C3=O)[CH2:8]2)[CH:2]=1>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([NH2:13])[CH2:8]2)[CH:2]=1

参加物

3

反応物 1

HCID 67133879cis-N-[3-(3-pyridyl)cyclohexyl]phthalimide

生成物 1

HCID 67134050cis-3-(3-Pyridyl)cyclohexylamine収率 36,904.199%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of cis-N-[3-(3-pyridyl)cyclohexyl]phtalimide (1.64 g, 5.35 mmol) and hydrazinemonohydorate (0.52 mL, 10.7 mmol) in EtOH (25 mL) was stirred at room temperature for 2 h. The reaction mixture was filtered followed by the removal of solvent. The crude product was purified by column chromatography (NH, EtOAc) to yield cis-3-(3-pyridyl)cyclohexylamine (348 g, 37%) as colorless oil.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customfollowed by the removal of solvent
  3. customThe crude product was purified by column chromatography (NH, EtOAc)

出典と根拠

ORDレコード
ord-3d83ef17f8a24d90af4e87a4c80cbbfe
出典データセット
uspto-grants-2011_12
特許番号
US08071591B2

反応ノート

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