Acetic Acid → Formylamino-thiophen-2-yl-acetic acid

HRID 655198ノート

反応式

HRID 655198 の反応式
[NH2:1][CH:2]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[C:3]([OH:5])=[O:4].[C:11](O)(=[O:13])C.O>C(O)=O>[CH:11]([NH:1][CH:2]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[C:3]([OH:5])=[O:4])=[O:13]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 962WaterHCID 894352-Thiopheneacetic acid, alpha-amino-, (-)-

生成物 1

HCID 21492681Formylamino-thiophen-2-yl-acetic acid

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

To a solution of amino-thiophen-2-yl-acetic acid (5 g) in formic acid (50 ml) was added acetic acid (18 ml). After stirring at room temperature for 6 h, water (25 ml) was added. The reaction mixture was stirred for 30 min. The mixture was concentrated in vacuo and triturated with water. The solids were collected by filtration and dried in vacuo (50° C.).

後処理

  1. stirringThe reaction mixture was stirred for 30 min
  2. concentrationThe mixture was concentrated in vacuo
  3. customtriturated with water
  4. filtrationThe solids were collected by filtration
  5. customdried in vacuo (50° C.)

出典と根拠

ORDレコード
ord-6d2f54b95a5640b48807c99fc7edca73
出典データセット
uspto-grants-2011_12
特許番号
US08071587B2

反応ノート

読み込み中…