Methanol → (7-Fluoro-quinolin-6-yl)-acetic acid methyl ester

HRID 655246ノート

反応式

HRID 655246 の反応式
F[C:2]1[C:11]([CH2:12][C:13]([OH:15])=[O:14])=[C:10]([F:16])[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.OS(O)(=O)=O.[CH3:22]O>C(OCC)(=O)C>[CH3:22][O:15][C:13](=[O:14])[CH2:12][C:11]1[CH:2]=[C:3]2[C:8](=[CH:9][C:10]=1[F:16])[N:7]=[CH:6][CH:5]=[CH:4]2

参加物

5

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 577423352-(5,7-Difluoroquinolin-6-yl)acetic acid

生成物 1

HCID 59320292(7-Fluoro-quinolin-6-yl)-acetic acid methyl ester収率 89.8%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of (5,7-difluoro-quinolin-6-yl)-acetic acid (18.6 g, 83.4 mmol) in methanol (200 mL) was added conc. H2SO4 (4.7 mL, 87.0 mmol). The reaction mixture was concentrated to give a brown residue, which was diluted with 200 ml of ethyl acetate, washed with sat. aq. NaHCO3 and brine, then the organic layer was dried over anhydrous Na2SO4, and concentrated to give (7-fluoro-quinolin-6-yl)-acetic acid methyl ester as yellow solid (17.7 g, yield: 89.8%).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customto give a brown residue, which
  3. washwashed with sat. aq. NaHCO3 and brine
  4. dry with materialthe organic layer was dried over anhydrous Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-5e75f868a01f4c48831bb8fedb09ace0
出典データセット
uspto-grants-2011_12
特許番号
US08071581B2

反応ノート

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