Methanol → (7-Fluoro-quinolin-6-yl)-acetic acid methyl ester

HRID 655251ノート

反応式

HRID 655251 の反応式
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[CH2:12][C:13]([OH:15])=[O:14].OS(O)(=O)=O.[CH3:21]O>C(OCC)(=O)C>[CH3:21][O:14][C:13](=[O:15])[CH2:12][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[F:1])[N:9]=[CH:8][CH:7]=[CH:6]2

参加物

5

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 468356122-(7-Fluoroquinolin-6-yl)acetic acid

生成物 1

HCID 59320292(7-Fluoro-quinolin-6-yl)-acetic acid methyl ester収率 98%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of (7-fluoro-quinolin-6-yl)-acetic acid (13.4 g, 65.36 mmol) in methanol (140 mL) was added conc.H2SO4 (3.5 mL, 68.63 mmol). The reaction mixture was concentrated to give a brown residue, which was diluted with 100 ml of ethyl acetate, washed with sat. aq. NaHCO3 and brine, then the organic layer was dried over anhydrous Na2SO4, and concentrated to give (7-fluoro-quinolin-6-yl)-acetic acid methyl ester as yellow solid (14.0 g, yield: 98%).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customto give a brown residue, which
  3. washwashed with sat. aq. NaHCO3 and brine
  4. dry with materialthe organic layer was dried over anhydrous Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-a246ffe110d644489761b10db1a7e158
出典データセット
uspto-grants-2011_12
特許番号
US08071581B2

反応ノート

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