Acetic Acid → HCID 57742362、化合物

HRID 655303ノート

反応式

HRID 655303 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([CH2:12][C:13]1[N:14]([NH2:19])[C:15]([NH2:18])=[N:16][N:17]=1)=[CH:7][CH:6]=2.[CH:20]([CH:22]=O)=O.C(O)(=O)C>O>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([CH2:12][C:13]1[N:14]3[N:19]=[CH:20][CH:22]=[N:18][C:15]3=[N:16][N:17]=1)=[CH:7][CH:6]=2

参加物

5

反応物 3

HCID 176Acetic AcidHCID 7860GlyoxalHCID 57742338HCID 57742338、化合物

生成物 1

HCID 57742362HCID 57742362、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5-(3-bromo-quinolin-6-ylmethyl)-[1,2,4]triazole-3,4-diamine (977 mg, 3 mmol), glyoxal (40% solution in water, 5 mL), acetic acid (10 mL) and water (2 mL) was stirred at ambient temperature for 18 hours. After such time the mixture was filtered and the filtrate was concentrated onto silica gel and via flash column chromatography (SiO2 12 g, dichloromethane/CH3OH, 0-10%) to return the title compound a white solid (298 mg, 29%). Analytical data presented in Table 1.

後処理

  1. filtrationAfter such time the mixture was filtered
  2. concentrationthe filtrate was concentrated onto silica gel and via flash column chromatography (SiO2 12 g, dichloromethane/CH3OH, 0-10%)

出典と根拠

ORDレコード
ord-a46a1aac0b64403fa16bdb875cc8fcba
出典データセット
uspto-grants-2011_12
特許番号
US08071581B2

反応ノート

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